Purpose: To evaluate the efficacy and safety of single-incision mini-sling for stress urinary incontinence based on network Meta-analysis. Materials and Methods: We searched PubMed, Embase, and Cochrane libraries from August 2008 to August 2019. Randomized controlled trials comparing two or more indicators of Miniarc (Single Incision Mini-slings), Ajust (Adjustable Single-Incision Sling), C-NDL (Contasure-Needleless), TFS (Tissue Fixation System), Ophria (Transobturator Vaginal Tap), TVT-O (Transobturator Vaginal Tape), and TOT (Trans-obturatortape) in treating female stress urinary incontinence were collected. Results: Totally, 3,428 patients from 21 studies were included. Ajust had the highest subjective cure rate (Rank = 0.52), while Ophira had the worst (Rank = 0.67). TFS had the highest objective cure rate, and the worst was found in Ophira. TFS required the shortest operating time (Rank = 0.40), while TVT-O required the longest operating time (Rank = 0.47). Miniarc had the least bleeding (Rank = 0.47), while TVT-O had the most bleeding (Rank = 0.37). C-NDL had the shortest postoperative hospital stay (Rank=0.77), while Ajust had the longest postoperative hospital stay (Rank = 0.36). For postoperative complications, TFS performed best in groin pain (Rank = 0.84), urinary retention (Rank = 0.78), and repeat surgery (Rank=0.45). TVT-O performed worst in groin pain (Rank = 0.36), and urinary retention (Rank = 0.58). Miniarc had the highest repeat surgery rate (Rank = 0.35). Ajust had the lowest probability of tap erosion (Rank=0.30), while Ophira had the highest tap erosion level (Rank = 0.45). Miniarc showed the greatest advantage in urinary tract infections (Rank = 0.84) and de novo urgency (Rank = 0.60), while C-NDL had the highest incidence of urethral infections (Rank = 0.51). Ophira performed worst in de novo urgency (Rank = 0.60). C-NDL performed the best in sexual intercourse pain (Rank = 0.79) while Ajust was the worst (Rank = 0.49). Conclusion: In view of comprehensive efficacy and safety, we recommend that TFS or Ajust should be selected first for single-incision sling and the application of Ophria should be minimized. [ABSTRACT FROM AUTHOR]