Full length TPP2 is present in the control but absent in the patient confirming TPP2 deficiency. 1 Histology of bone marrow, lymph node, and mediastinal mass biopsy. a Bone marrow trephine histology normal trilineage hematopoiesis, no plasma cell excess or macrophage infiltrate. b Lymph node biopsy showing retained architecture with B cell follicles and extensive plasmacytosis as shown in c lymph node biopsy CD138 IHC. Previous studies of TPP2-deficient patients (P1) showed that TPP2 deficiency was associated with premature T cell senescence and increased expression of CD57 on the CD8 T cells. [Extracted from the article]