Dipeptidase-1 governs renal inflammation during ischemia reperfusion injury.
- Resource Type
- Article
- Authors
- Lau, Arthur; Rahn, Jennifer J.; Chappellaz, Mona; Hyunjae Chung; Benediktsson, Hallgrimur; Bihan, Dominique; von Mässenhausen, Anne; Linkermann, Andreas; Jenne, Craig N.; Robbins, Stephen M.; Senger, Donna L.; Lewis, Ian A.; Chun, Justin; Muruve, Daniel A.
- Source
- Science Advances. 2/4/2022, Vol. 8 Issue 5, p1-10. 10p.
- Subject
- *REPERFUSION injury
*SELENOPROTEINS
*BETA lactam antibiotics
*PROXIMAL kidney tubules
*CELL adhesion molecules
*CD54 antigen
*GREEN fluorescent protein
*MACROPHAGE migration inhibitory factor
- Language
- ISSN
- 2375-2548
The article offers information about how dipeptidase-1 has governed renal inflammation during ischemia reperfusion injury. It mentions that mechanisms that drive leukocyte recruitment to the kidney as incompletely understood. Dipeptidase-1 (DPEP1) as a major neutrophil adhesion receptor highly expressed on proximal tubular cells and peritubular capillaries of the kidney.