Profiling of steroid metabolites after transdermal and oral administration of testosterone by ultra-high pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometry.
- Resource Type
- Article
- Authors
- Badoud, F.; Boccard, J.; Schweizer, C.; Pralong, F.; Saugy, M.; Baume, N.
- Source
- Journal of Steroid Biochemistry & Molecular Biology. Nov2013, Vol. 138, p222-235. 14p.
- Subject
- *STEROID metabolism
*TRANSDERMAL medication
*HIGH performance liquid chromatography
*QUALITATIVE research
*QUADRUPOLE mass analyzers
*CLINICAL trials
*BIOMARKERS
*TIME-of-flight mass spectrometry
- Language
- ISSN
- 0960-0760
Highlights: [•] New generation QTOF quantitative measurements of urinary endogenous steroid profile. [•] 19 male volunteers with different UGT2B17 genotypes took part in a clinical trial. [•] Testosterone metabolism evaluation via transdermal and oral route of administration. [•] Pertinence of sulfoconjugated metabolites, particularly for del/del individuals. [•] Relevance of OH-metabolites as potential markers of long term testosterone doping. [ABSTRACT FROM AUTHOR]