Introduction: Type 1 diabetes is one of the most chronic childhood diseases. The therapeutic recommendation for this condition is complex and needs lifestyle changes. Recently, the role of gut microbiota has received attention as a possible mechanism in the pathogenesis and control of the disease. Methods: A total of 130 children aged 6-18 years with newly diagnosed type 1 diabetes will participate in this trial. They are randomly assigned to the intervention and control group. The patients will receive a six-month course of probiotics or placebo in addition to their conventional treatment with insulin, and they are followed for at least one year. Participants are followed at 3-month intervals for one year. At each visit, anthropometrical data, glycemic control, and total dose of insulin required to keep the optimal glycemic control are evaluated and registered. Discussion: There is evidence that alterations in gut microbiota is seen in children with diabetes. In this study, we aim to evaluate the effect of probiotic administration on the duration of the honeymoon period in pediatrics with type 1 diabetes and their glycemic control and insulin requirements. [ABSTRACT FROM AUTHOR]