Utilizing the midpoint concentration, we estimated the AUC using the short infusion vancomycin model. Our aim was to compare the accuracy and precision of estimating AUC using vancomycin midpoint concentrations, compared against the two-level Bayesian-based gold standard approach. We hypothesized that a single vancomycin concentration obtained at midpoint may offer an alternative method to estimating vancomycin area-under-the-curve (AUC) in cases where the recommended Bayesian-based approach is not available. [Extracted from the article]