Keywords: algorithm; antiviral drugs; COVID-19; outpatients; treatment EN algorithm antiviral drugs COVID-19 outpatients treatment 107 109 3 01/18/23 20230201 NES 230201 Key points Early treatment of high-risk patients with COVID-19 could significantly decrease hospitalizations, intubations and deaths. Management of moderate severity outpatients with COVID-19 disease: Proposed criteria and algorithm for initiation of antiviral treatment In this paper, we propose a simplified algorithm for the management of COVID-19 infection in outpatients, to achieve early treatment initiation to reduce hospitalizations, intubations and deaths. [Extracted from the article]