We performed studies on the influence of hyperbaric oxygen therapy on the trophic ulceration of the crus using thermal imaging and TC oximetry. Thermograms for two groups of volunteers, one suffering from trophic ulceration of the crus (11 patients aged 63.6 ± 15.2) and one healthy (6 people aged 42 ± 8), were completed before and after hyperbaric oxygenation. In addition, the oxygen tension in each patient's crus was measured. Hyperbaric oxygenation has an influence on biological as well as physiological processes that occur in the tissue. It is apparent that these processes may have an impact on the differentiation of tissue temperature. The studies showed some differences in skin temperature between research groups. A bigger differentiation of skin temperature was observed for patients who suffered from ulceration. It follows that there are statistically significant differences between the mean temperature for all chosen regions of interest obtained before ( p = 0.0003) and after ( p = 0.03) hyperbaric oxygen therapy. Moreover, the differences (Δ T = T − T) between mean temperature characterization in chosen areas seem to be a little smaller. We observed that this difference changed from Δ T = 3.3 °C, estimated before hyperbaric oxygenation, to 2.5 °C, obtained after hyperbaric oxygenation, which may suggest improvement in the thermoregulation process. A similar situation was observed for the healthy group, but the temperature changes were smaller. The changes of the mean temperature may be correlated to some changes in wound cellular metabolism and the increase of microcirculation due to neoangiogenesis as well as the improvement of thermoregulation in the ulceration due to a rebuilding of the right cellular matrix. In addition, we observed that the mean values of oxygen pressure in the tissues (TCPO2) increased from 22 to 39 mmHg after hyperbaric oxygenation for patients with ulceration in their lower extremities. We also detected that oxygen pressure measurements and infrared imaging seem to be useful in the qualitative analysis of hyperbaric oxygenation treatment, and may offer some useful information about the hyperbaric oxygen therapy effects in trophic ulceration. [ABSTRACT FROM AUTHOR]