Transcriptomics, proteomics, metabolomics and network pharmacology reveal molecular mechanisms of multi-targets effects of Shenxianshengmai improving human iPSC-CMs beating (C) Chemical structure of the reference substance of representative identified monomer components. gl Subsequently, transcriptomics-proteomics-metabolomics revealed the molecular mechanism of SXSM improving the beating of human iPSC-CMs (Supplementary Document 1). (C) O2PLS joint loadings plot of metabolites and genes in response to Shenxianshengmai (SXSM) treatment of human iPSC-CMs. As previous studies showed that the effects of SXSM were strongly associated with adrenoceptor-related pathways,[[1]] isoproterenol (ISO) was used to compare with SXSM regarding the effect on human iPSC-CMs (Figure S2A-M). [Extracted from the article]