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요약정보
磷酸化或乙酰化修饰使 Fascin 的促癌功能翻转.
Resource Type
Article
Authors
李大嘉
;
许丽艳
;
程银伟
;
李恩民
Source
Chinese Journal of Biochemistry & Molecular Biology
. May2024, Vol. 40 Issue 5, p674-684. 11p.
Subject
Language
Chinese
ISSN
1007-7626
Online Access
Scopus
Find it @ DONGA
초록
大量研究结果表明, 食管鳞癌等恶性肿瘤中, Fascin异常高表达并发挥促癌功能, 其与癌症患者的不良预后密切相关。近年来, 包括本实验室在内, 多家实验室的研究结果一致表明, 磷酸化或乙酰化修饰可使 Fascin 的促癌功能翻转, 犹如川剧中的 “变脸”。最近, 本室进一步研究发现, Fascin 的翻译后修饰明显影响 Fascin 小分子抑制剂的抑癌效果, 提示以 Fascin 为靶点的抗肿瘤药物研究应该将 Fascin 翻译后修饰状态纳入是否适合用药的评价体系中。为此, 本文在系统评述 Fascin 促癌功能的基础上, 重点讨论了翻译后修饰对 Fascin 功能的调控作用, 以及翻译后修饰对 Fascin 小分子抑制剂抑癌功效的影响;同时还对相关领域针对 Fascin 的未来研究趋势进行了展望。 [ABSTRACT FROM AUTHOR]
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