MOOC is a large-scale open online course, and is the product of "Internet plus education". The emergence of MOOC has brought about a new round of reform in teaching mode. Online to offline mixed teaching mode is a new teaching mode which can enhance the interaction between teachers and students and give full play to the main body of students. Based on the study of MOOC, this paper makes a beneficial attempt to apply the mixed teaching mode in the course teaching reform, practice has proved that the teaching mode can promote students’ independent thinking, stimulate students’ innovative thinking, and effectively improve students’ post ability.