Cu(i)/Amino Acid Catalyzed Coupling Reactions of Aryl Halides and Nucleophiles: Applications in Large-scale Production
- Resource Type
- article
- Authors
- Dawei Ma; Yongwen Jiang
- Source
- CHIMIA, Vol 65, Iss 12 (2011)
- Subject
- Copper-catalyzed coupling reactions
L-proline
Ullmann-type coupling reactions
Chemistry
QD1-999
- Language
- German
English
French
- ISSN
- 0009-4293
2673-2424
Amino acids can be used as ligands to promote Ullmann-type coupling reactions. This review briefly discusses how L-proline, 4-hydroxy-L-proline and N,N-dimethylglycine can serve as the ideal ligands for copper-catalyzed coupling of aryl halides with different nucleophiles. Seven examples of applications of copper/amino acid catalyzed reactions in large-scale preparations are described.