Carboxypeptidase E, a Prohormone Sorting Receptor, Is Anchored to Secretory Granules...
- Resource Type
- Article
- Authors
- Dhanvantari, Savita; Arnaoutova, Irina; Snell, Chris R.; Steinbach, Peter J.; Hammond, Kelli; Caputo, Gregory A.; London, Erwin; Loh, Y. Peng
- Source
- Biochemistry. 1/8/2002, Vol. 41 Issue 1, p52. 9p. 7 Diagrams, 3 Graphs.
- Subject
- *CARBOXYPEPTIDASES
*LIPIDS
- Language
- ISSN
- 0006-2960
Examines the structure and orientation of the membrane-binding domain at the C-terminus of carboxypeptidase E (CPE), a sorting receptor that directs the prohormone pro-opiomelanocortin to the regulated secretory pathway. Adoption by the CP peptide of a partial alpha-helical configuration at low pH; Increase in helix content when the peptide is bound to lipid.