Neurocognitive Improvement with Hydroxyurea Therapy in Children with Sickle Cell Anemia in Uganda: Interim Analysis at Month 18
- Resource Type
- Article
- Authors
- Naggayi, Shubaya Kasule; Kalibala, Dennis; Opoka, Robert; Rosano, Caterina; Munube, Deogratias; Kasirye, Phillip; Mupere, Ezekiel; Mboizi, Vincent; Ssenkusu, John; Green, Nancy S.; Idro, Richard; Bangirana, Paul
- Source
- Blood; November 2023, Vol. 142 Issue: 1, Number 1 Supplement 1 p275-275, 1p
- Subject
- Language
- ISSN
- 00064971; 15280020
Introduction:Cerebrovascular injury can lead to neurocognitive impairment in children with sickle cell anemia (SCA). The prospective impact of hydroxyurea therapy on neurocognitive function has not been previously reported in a large sample of children with SCA in sub-Saharan Africa. We assessed the impact of hydroxyurea therapy at the trial's18-month midpoint on neurocognitive function compared to baseline assessments and to non-SCA controls.