Spatial airflow impact source localization is vital for security detection, which lack of effective positioning technology. Herein, this article presents a spatial airflow impact source positioning system based on microelectromechanical system (MEMS) pressure sensor array. A piezoresistive pressure sensor with a sensitivity of 28 mV/MPa is fabricated by the MEMS technology. To position the airflow impact source accurately, we array the MEMS pressure sensors on a flexible and wearable substrate. Four arrayed sensors are essential for positioning a spatial airflow impact source, and the experimental results demonstrate the feasibility of the scheme with coordinates errors ( ${X}$ : 1.93 mm, ${Y}$ : 2.29 mm, and ${Z}$ : 3.30 mm). AIso, we develop a $3\times3$ type pressure sensors array structure to enhance the positioning accuracy, which improves the triaxial coordinates localization accuracy 96.9%, 87.8%, and 74.9%, respectively. This work provides a reliable method for spatial airflow impact source accurately positioning with a potential application of wearable devices.