Both Fusobacterium nucleatum(F. nucleatum) and long non-coding RNA (lncRNA) EVADRare associated with colorectal cancer (CRC), but their relationship with CRC metastasis and the mechanisms by which EVADRpromotes CRC metastasis are poorly understood. Here, we report that F. nucleatumpromotes colorectal cancer cell metastasis to the liver and lung and that it can be detected in CRC-metastasis colonization in mouse models. Furthermore, F. nucleatumupregulates the expression of EVADR, which can increase the metastatic ability of CRC cells in vivoand in vitro. Mechanistically, elevated EVADRserves as a modular scaffold for the Y-box binding protein 1 (YBX1) to directly enhance the translation of epithelial-mesenchymal transition (EMT)-related factors, such as Snail, Slug, and Zeb1. These findings suggest that EVADRinduced by F. nucleatumpromotes colorectal cancer metastasis through YBX1-dependent translation. The EVADR-YBX1 axis may be useful for the prevention and treatment of patients with F. nucleatum-associated CRC metastasis.