Natural compound library screening identifies Sanguinarine chloride for the treatment of SCLC by upregulating CDKN1A
- Resource Type
- Article
- Authors
- Zhong, Mingtian; Li, Xun; Zhao, Fengyun; Huang, Yanni; Long, Yihao; Chen, Kaizhao; Tian, Xuemei; Liu, Ming; Ma, Xiaodong
- Source
- Translational Oncology; March 2022, Vol. 17 Issue: 1
- Subject
- Language
- ISSN
- 19447124; 19365233
•Natural compound library screening identified Sanguinarine chloride as a tumor suppressor in SCLC.•Sanguinarine chloride exhibits anti-SCLC ability in vitroand in vivo.•Sanguinarine chloride upregulates CDKN1A to suppress SCLC development.•Sanguinarine chloride enhances the anti-tumor effect of panobinostat in SCLC by promoting cell cycle arrest.