A lamellar-structure TC21 titanium alloy was hot-rolled and subsequently annealed at 820, 880 and 940 °C for 1 and 6 h, and the effects of annealing parameters on static globularization and morphology evolution of both αand βphases were studied. The results show that αglobularization process is sluggish due to the limited boundary splitting at 820 °C. With increasing temperature to 880 °C, the accelerated boundary splitting and termination migration promote the αglobularization. At 820 and 880 °C, the static recovery (SRV) and recrystallization (SRX) induce the grain refinement of interlamellar βphase. However, the excessively high temperature of 940 °C results in the coarsening of αgrains due to the assistance of Ostwald ripening, and produces coarse βgrains mainly due to the absence of SRX in interlamellar βphases. Conclusively, 880 °C is an appropriate annealing temperature to produce a homogeneous microstructure in which globularized αand refined βgrains distribute homogeneously.