Bacillus anthracisand Yersinia pestis, the causative pathogens for anthrax and plague, respectively, along with Burkholderia malleiand Burkholderia pseudomalleiare potential bioterrorism threats. Tebipenem pivoxil hydrobromide (TBP HBr) (formerly SPR994) is an orally available prodrug of tebipenem, a carbapenem with activity versus multidrug-resistant (MDR) Gram-negative pathogens, including quinolone-resistant and extended-spectrum-β-lactamase-producing Enterobacterales.