Co2(CO)8as a Solid CO (g) Source for the Amino Carbonylation of (Hetero)aryl Halides with Highly Deactivated (Hetero)arylamines
- Resource Type
- Article
- Authors
- Cheruku, Srinivas; Sajith, Ayyiliath M; Narayana, Yatheesh; Shetty, Poornima; Nagarakere, Sandhya C; Sagar, Kunigal S; Manikyanally, Kumara N; Rangappa, Kanchugarkoppal Subbegowda; Mantelingu, Kempegowda
- Source
- The Journal of Organic Chemistry; 20210101, Issue: Preprints
- Subject
- Language
- ISSN
- 00223263
Carbonylation of (hetero)aryl iodides/bromides with highly deactivated 2-aminopyridines using Pd–Co(CO)4bimetallic catalysis is accomplished. The use of Co2(CO)8as a solid CO(g) source enhanced reaction rates observed when compared to CO(g), and excellent yields highlight the versatility of the developed protocol. A wide range of electronically and sterically demanding heterocyclic amines and (hetero)aryl iodides/bromides employed for this study resulted in excellent yields of amino carbonylated products. The developed methodology was further extended to synthesize Trypanosome brucieand luciferase inhibitors.