Peripheral and Central Chemical Control of Pulmonary Ventilation.
- Resource Type
- Article
- Authors
- Owen, Harriet; Gesell, Robert
- Source
- Experimental Biology and Medicine; April 1931, Vol. 28 Issue: 7 p765-766, 2p
- Subject
- Language
- ISSN
- 15353702; 15353699
Until the recent work of Heymans there has been little evidence for reflex chemical control of pulmonary ventilation. The demonstration of increased respiratory movements from perfusion of the carotid sinus with carbonated and deoxygenated blood calls for a study of the relative values of peripheral and central chemical control.1Several procedures were used.The effects of injection of sodium cyanide, sodium sulphide, sodium carbonate and sodium bicarbonate into the carotid arteries after occlusion of the vertebral and external carotid arteries and denervation of one carotid sinus were noted. Injection of sodium cyanide on the side on which the innervation of the carotid sinus was intact invariably produced increased ventilation. Injection on the denervated side produced relatively small or no increase in ventilation followed by depression. In general the effects of intraarterial injection of sodium sulphide were similar to those produced by cyanide. Painting the innervated sinus with sodium cyanide or sulphide elicited increased ventilation. This response was demonstrated to be due to local action. Intravenous injection of sodium cyanide or sulphide after double vagotomy and double sinus denervation was relatively ineffective or entirely ineffective in augmenting ventilation. Late depression of ventilation was not uncommon. Similar results were obtained if the common carotid arteries and the internal occipital arteries were occluded as a substitute for denervation. Injection of cyanide into the 4th ventricle was found to produce immediate excitation or depression without initial excitation. It was concluded that this action was local. In several experiments in which sodium sulphide was injected into the fourth ventricle, immediate, well sustained and marked augmentation of ventilation invariably occurred.