Gene polymorphisms and HLA-G expression in spontaneous abortions
- Resource Type
- Article
- Authors
- García-Láez, Virginia; Serra, Vicente; Bellver, José; Ferro, Jaime; Vidal, Carmina; De los Santos, José María; Rubio, Mari Carmen; Martín, Julio; Martínez, Carmen; De los Santos, María José
- Source
- Medicina Reproductiva y Embriología Clínica; December 2015, Vol. 2 Issue: 3 p82-92, 11p
- Subject
- Language
- ISSN
- 23409320
HLA-G and HLA-E are claimed to play a role in establishing maternal–fetal immune tolerance and in maintaining pregnancy. The presence of polymorphism in the HLA-G gene could cause a deficient or excessive expression of the HLA-G and HLA-E molecules. These anomalies could eventually cause pregnancy losses.