Isolation of Talathermophilins from the Thermophilic Fungus Talaromyces thermophilusYM3-4
- Resource Type
- Article
- Authors
- Guo, Ji-Peng; Tan, Jian-Lin; Wang, Yan-Li; Wu, Hong-Yang; Zhang, Chuan-Ping; Niu, Xue-Mei; Pan, Wen-Zheng; Huang, Xiao-Wei; Zhang, Ke-Qin
- Source
- Journal of Natural Products; October 2011, Vol. 74 Issue: 10 p2278-2281, 4p
- Subject
- Language
- ISSN
- 01633864; 15206025
Six indole alkaloids with various levels of prenylation were isolated from the thermophilic fungus Talaromyces thermophilusstrain YM3-4. Their structures were identified by NMR and MS spectroscopic analyses. Compounds 1and 2are new analogues of the key versatile precursor notoamide E. Compound 3is a novel analogue of preechinulin, and compound 4was reported as a natural occurring cyclo(glycyltryptophyl) for the first time. The metabolite profile of this thermophilic organism displayed a biosynthetic pathway for talathermophilins.