Isotope or mass encoding of combinatorial libraries
- Resource Type
- Article
- Authors
- Geysen, H. Mario; Wagner, Craig D.; Bodnar, Wanda M.; Markworth, Christopher J.; Parke, Gillian J.; Schoenen, Frank J.; Wagner, David S.; Kinder, Daniel S.
- Source
- Chemistry & Biology; 1996, Vol. 3 Issue: 8 p679-688, 10p
- Subject
- Language
- ISSN
- 10745521
Background:Combinatorial chemistry using solid-phase synthesis is a rapidly developing technology that can result in a significant reduction in the time required to find and optimize lead compounds. The application of this approach to traditional medicinal chemistry has led to the construction of libraries of small organic molecules on resin beads. A major difficulty in developing large combinatorial libraries is the lack of a facile encoding and decoding methodology to identify active compounds.