Autophagy prevents microglial senescence
- Resource Type
- Brief Communication
- Authors
- Amin, Sadaf; Liu, Bangyan; Gan, Li
- Source
- Nature Cell Biology. 25(7):923-925
- Subject
- Language
- English
- ISSN
- 1465-7392
1476-4679
Disruptions in the autophagy–lysosome pathway in neurons have been implicated in Alzheimer’s disease. A study now reports that autophagy is also critical for disease-associated microglia surrounding amyloid plaques and is protective against microglial senescence and neuropathology in an Alzheimer’s disease mouse model.