Papillary thyroid cancer’s (PTC) prognosis is better than other thyroid cancers but prognosis is worse developing on autoimmune basis. The aim of this study is to find the effect of tumor morphology or histopathological factors on TSH receptor antibody (TRAb) development in patients with subclinical hyperthyroidism who have thyroid papillary cancer. Eight hundred ninety-eight patients who underwent thyroidectomy in the Department of General Surgery in Ankara City Hospital between 2011 and 2019 were analyzed retrospectively. One hundred eight patients who were diagnosed with papillary thyroid cancer and low thyroid-stimulating hormone (TSH) levels were identified. We separated the cases into two as. TRAb value in the reference range and TRAb value was positive. The relationship between TRAb and laboratory parameters, age, gender, and echogenicity status in preoperative ultrasonography (USG), tumor size, and tumor localization was investigated. There were 51 patients in TRAb ( +) group and 53 patients in TRAb value normal limits group. There was no significant difference in age, gender, pathological subtypes, and tumor localization distribution between groups. Negative correlation was found between TSH and TRAb (p = 0.018); positive correlation was found between tumor size and TRAb (p < 0.01). As the tumor size increases, the probability of TRAb level being above the reference range increases. According to our results, as the nodule size increases and TSH level decreases in hyperthyroidic papillary thyroid cancers, TRAb positivity, the probability of developing on an autoimmune disease background increases.