Purpose: This review aims to provide an overview of current knowledge and future perspectives on sentinel node biopsy in gynaecological cancers.Methods: Literature research in the PubMed/MEDLINE database was carried out to identify relevant studies on sentinel node biopsy in gynaecological cancers. We selected only original studies, published in the English language and including a minimum of nine patients.Results: The most relevant results on sentinel node biopsy in gynaecological cancers were summed up, focusing on clinical indications, technical aspects, preoperative and intraoperative procedures and the latest technological advances.Conclusion: Sentinel node biopsy has been widely validated in well-selected patients with early-stage vulvar, cervical and endometrial cancers. It is essential to standardise the acquisition protocol, including SPECT/CT imaging, for an improved surgical planning and a personalised approach. Recent technological advances, such as hybrid tracers and intraoperative tools, may efficiently guide gynaecological cancer surgery.