Peptides are versatile molecular tools that can self-assemble and participate in molecular recognition processes. Our group has developed rationally designed peptides that (1) bind to the inside of microtubules and (2) cause light-induced peptide nanofiber growth. This focus review describes the construction of new bio-nanoarchitectures using these peptide-based technologies. A newly developed Tau-derived peptide was used to encapsulate various nanomaterials inside microtubules, thereby modulating the structure and function of the microtubules. Moreover, the propulsion of micrometer-sized spheres driven by light-induced peptide nanofiber growth was accomplished. These methods represent new concepts for bio-nanomaterials that mimic, control and surpass natural systems.
Peptides are versatile molecular tools with molecular recognition capabilities, high designability, and the capacity for self-assembly. In this focus review, the construction of new bio-nanoarchitectures using our peptide-based technologies is described. First, the construction of functional microtubules was achieved by molecular encapsulation using a Tau-derived peptide. Second, light-induced peptide nanofiber growth was used for the development of artificial motile systems of micrometer-sized spheres. The development of bio-nanoarchitectures by these peptide-based approaches is useful for understanding, mimicking, and controlling natural nano/microstructures.