LRH-1: orphaned, adopted and needed for pregnancy
- Resource Type
- Brief Communication
- Authors
- Brosens, Jan J; Blanks, Andrew M; Lucas, Emma S
- Source
- Nature Medicine. 19(8):968-969
- Subject
- Language
- English
- ISSN
- 1078-8956
1546-170X
A new study shows that the orphan nuclear receptor liver receptor homolog 1 (LRH-1) wires the postovulatory rise in progesterone production to progesterone-dependent preparation of the endometrium for pregnancy, a process termed decidualization. Lack of Lrh-1 activity in either the ovary or uterus has catastrophic consequences for reproduction in mice (pages 1061–1066).