Eggs made from male mouse stem cells using error-prone culture
- Resource Type
- News
- Authors
- Bayerl, Jonathan; Laird, Diana J.
- Source
- Nature: International weekly journal of science. 615(7954):805-807
- Subject
- Developmental biology
Stem cells
Biological techniques
- Language
- English
- ISSN
- 0028-0836
1476-4687
A screen of mouse stem cells that exploits their propensity to gain or lose chromosomes in cell culture has been used to convert male XY to female XX cells. Subsequent differentiation generates functional eggs and live offspring.
Protocol to generate XX eggs from XY mouse embryonic stem cells.