A rare genetic variant biases maternal meiotic recombination toward risk of pregnancy loss
- Resource Type
- Brief Communication
- Authors
- Carioscia, Sara A.; McCoy, Rajiv C.
- Source
- Nature Structural & Molecular Biology. 31(4):584-585
- Subject
- Language
- English
- ISSN
- 1545-9993
1545-9985
Pregnancy loss is common in humans, but maternal genetic factors modulating its incidence are largely unknown. In a meta-analysis of genome-wide association studies, researchers identified a genetic variant that seems to increase risk of pregnancy loss by dysregulating meiotic recombination between homologous chromosomes during egg formation.