A series of studies have suggested proven that a geomagnetic storm can accelerate the formation of plasma depletions and the generation of ionospheric irregularities. Using observation data from the Continuously Operating Reference Stations (CORS) network in the USA, the responses of the ionospheric total electron content (TEC) to the geomagnetic storm on September 8, 2017 are studied in detail. A mid-latitude trough was discovered from 01:00 UT to 06:00 UT in the USA with a length exceeding 5000 km. Medium-scale travelling ionospheric disturbances (MSTID) with wavelengths of 600–700 km were generated accompanied by a drop and perturbation in the electron density. The intensity of the MSTID fluctuations reached over 2.5 TECU, which were discovered by filtering the differential TEC. SWARM spaceborne observations also showed a drop in the electron density from 105 to 103 compared to the background values at 28° N, 96° W, and 25° N, 95° W. This research investigates super-scale plasma depletions generated by geomagnetic storms using both CORS GNSS and spaceborne observations. The proposed work is valuable for better understanding the evolution of ionospheric depletions during geomagnetic storms.