One-step fabrication of biocompatible chitosan-coated ZnS and ZnS:Mn2+ quantum dots via a γ-radiation route
- Resource Type
- Brief Communication
- Authors
- Chang, Shu-quan; Kang, Bin; Dai, Yao-dong; Zhang, Hong-xu; Chen, Da
- Source
- Nanoscale Research Letters. December 2011 6(1):1-7
- Subject
- quantum dots
γ-radiation
chitosan
ZnS
ZnS:Mn2+
biocompatible
- Language
- English
- ISSN
- 1556-276X
Biocompatible chitosan-coated ZnS quantum dots [CS-ZnS QDs] and chitosan-coated ZnS:Mn2+ quantum dots [CS-ZnS:Mn2+ QDs] were successfully fabricated via a convenient one-step γ-radiation route. The as-obtained QDs were around 5 nm in diameter with excellent water-solubility. These QDs emitting strong visible blue or orange light under UV excitation were successfully used as labels for PANC-1 cells. The cell experiments revealed that CS-ZnS and CS-ZnS:Mn2+ QDs showed low cytotoxicity and good biocompatibility, which offered possibilities for further biomedical applications. Moreover, this convenient synthesis strategy could be extended to fabricate other nanoparticles coated with chitosan.PACS: 81.07.Ta; 78.67.Hc; 82.35.Np; 87.85.Rs.