LAG3 disrupts the TCR signal by local acidification
- Resource Type
- Brief Communication
- Authors
- Hivroz, Claire
- Source
- Nature Immunology. 23(5):649-651
- Subject
- Language
- English
- ISSN
- 1529-2908
1529-2916
LAG3 interferes with TCR signaling by lowering the pH in the vicinity of the TCR and inducing dissociation of the key signaling kinase Lck from the co-receptors CD8 and CD4.