Addressing environmental pollution, the present study proposes the utilization of natural products as alternatives to chemical additives in soap manufacturing. Specifically, the study explores the potential of the above-ground parts of Paris polyphylla (AGPP), an abundant but underexploited resource, in contrast to its overexploited and endangered underground parts of Paris polyphylla (UGPP). The AGPP was extracted with 75% (V/V) ethanol, yielding a significantly higher content of saponin VII compared to the UGPP extract (41.02 mg/g vs. 10.41 mg/g). Radical scavenging assays demonstrated the extract’s effectiveness against DPPH, hydroxyl, and superoxide anion radicals. The extract was subsequently incorporated into a soap base, optimized via D-optimal mixture design to comprise 20.5% coconut oil, 42.5% olive oil, and 37% palm oil. Antibacterial studies indicated that the soap containing AGPP extract exhibited potent activity against Candida albicans and Propionibacterium acnes. These findings suggest the promising role of AGPP extract as a natural antioxidant and antimicrobial agent in the formulation of eco-friendly soap