Prevalence of the precore G1896A mutation in Chinese patients with e antigen negative hepatitis B virus infection and its relationship to pre-S1 antigen
- Resource Type
- article
- Authors
- Zhang, Jing; Xu, Wei-Jia; Wang, Qing; Zhang, Yong; Shi, Ming
- Source
- Brazilian Journal of Microbiology. December 2009 40(4)
- Subject
- Hepatitis B virus
precore mutation
pre-S1
- Language
- English
- ISSN
- 1517-8382
This study investigated the prevalence of the precore G1896A mutation in Chinese patients with hepatitis B e antigen (HBeAg) negative HBV infection and its relation to serum HBV pre-S1 antigen. The overall prevalence of the precore G1896A mutation was 72.6% in HBeAg-negative Chinese patients with detectable serum HBV DNA. The prevalence of the precore G1896A is significantly higher in Chinese HBeAg-negative patients with chronic hepatitis B than that in inactive HBV carriers with detectable serum HBV DNA. Serum pre-S1 and the precore G1896A mutation were simultaneously detected in most of Chinese HBeAg-negative patients.