ABSTRACT: A 77-year-old man was referred for F-PSMA-1007 PET/CT scan for initial staging of biopsy-proved prostate adenocarcinoma. F-PSMA-1007 PET/CT showed focal intense F-PSMA-1007 of the prostate adenocarcinoma and a focal intense activity (SUVmax, 27) in the spleen. The F-PSMA-1007–avid splenic lesion corresponded to a splenic hemangioma, which was initially detected on contrast-enhanced CT 7 months ago and unchanged in size and enhancement pattern on follow-up contrast-enhanced CT. This case indicates that splenic hemangioma should be included in the differential diagnosis of PSMA-avid splenic lesions.