HIV–1 evades a gag mutation that abrogates KIR binding and disinhibits NK cells in infected individuals with KIR2DL2+/HLA–C*03: 04+ genotype
- Resource Type
- Academic Journal
- Authors
- Ziegler, Maja C.; Naidoo, Kewreshini; Chapel, Anais; Nkotwana, Sindiswa; Mann, Jaclyn; Mncube, Zenele; Ismael, Nasreen; Goulder, Philip; Ndung’u, Thumbi; Altfeld, Marcus; Thobakgale, Christina F.
- Source
- AIDS. Oct 08, 2020
- Subject
- Language
- English
- ISSN
- 0269-9370
HIV–1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leucocyte class I (HLA–I) molecules modulating NK cell function. HIV–1 strains encoding amino acids that mediate binding of inhibitory KIRs might therefore have a selective benefit in individuals expressing the respective KIR/HLA genotypes. Here we demonstrate that HIV–1 clade C avoids a p24 Gag mutation that abolishes binding of KIR2DL2 to HLA–C03:04 and disinhibits NK cells in individual encoding for this genotype.