PRECIS:: This retrospective case series of patients with open-angle glaucoma and prior trabeculectomy or tube shunt surgery found that selective laser trabeculoplasty resulted in significant intraocular pressure reductions in the intermediate follow up period in select cases. PURPOSE:: To assess IOP lowering effect and tolerability of SLT after prior trabeculectomy or tube shunt surgery. METHODS:: Open-angle glaucoma patients at Wills Eye Hospital with incisional glaucoma surgery prior to SLT from 2013 to 2018, and a control group were included. Baseline characteristics, procedural data, and post-SLT data were recorded at 1 month, 3 months, 6 months, 12 months and most recent visit. Primary success of SLT treatment was defined as IOP reduction at least 20% from baseline without the use of additional glaucoma medications compared to pre-SLT IOP. Secondary success was defined as IOP reduction ≥20% with use of additional glaucoma medications compared to pre-SLT IOP. RESULTS:: There were 45 eyes in the study group and 45 eyes in the control group. In the study group, IOP decreased from a baseline of 19.5±4.7 mmHg on 2.2±1.2 medications to 16.7±5.2 mmHg (P=0.002) on 2.2±1.1 glaucoma medications (P=0.57). In the control group, IOP decreased from 19.5±4.2 mmHg on 2.4±1.0 medications to 16.4±5.2 (P=0.003) on 2.1±1.3 medications (P=0.36). There was no difference in IOP reduction or change in number of glaucoma medications after SLT any post-operative visit between the 2 groups (P≥0.12 for all). Primary success rates at 12 months were 24.4% for the control group and 26.7% for the prior incisional glaucoma surgery group with no significant difference between the groups (P=0.92). There were no persistent complications after SLT treatment in either group. CONCLUSIONS:: SLT may effectively lower IOP in patients with open angle glaucoma who have had previous incisional glaucoma surgery and should be considered in select cases.