CASE:: A 69-year-old woman presented with a type IIIB left proximal humerus fracture with a 500-square-centimeter soft tissue defect, 10-cm bone defect, and radial nerve laceration after a tiger attack. The surgical intervention included proximal humeral replacement with muscular integration, radial nerve repair, and latissimus dorsi flap coverage. CONCLUSION:: This case presents an exceedingly rare injury mechanism resulting in a significant soft tissue and bone defect. Its novelty lies in the complexity of the injury, which required a well-coordinated multispecialty treatment approach. This strategy applies to injuries with similar extensive soft tissue and bone defects.