BACKGROUND:: Patients with cervical spondylosis of single or double segments are mainly treated with anterior decompression and internal fixation. The therapy selection of multilevel cervical spondylosis is still in dispute. OBJECTIVE:: To discuss the surgical method and clinical effect of anterior hybrid decompression technique (subtotal single vertebrectomy combined with intervertebral discectomy) in treatment of multilevel cervical spondylosis. METHODS:: Retrospective analysis was performed in 30 patients with multilevel cervical spondylosis. All the patients received anterior hybrid decompression, autogenous iliac bone grafting or ZEPHIR plate internal fixation. The neurological function scores, fusion rates, cervical physiological curvature and intervertebral height, and complications of patients were analyzed after treatment. RESULTS AND CONCLUSION:: The patients were followed up for 12-72 months, with an average of 36 months. The cervical physiological curvature and the intervertebral height were significantly improved after surgery. The spinal cord of oppressed segments was well bulged. Loosening, fracture and displacement of the plates and screws were not found during the follow-up. The postoperative fusion rate was 100% at 6 months. The Japanese Orthopaedic Association scores were obviously improved after 12 months of follow-up. The improvement rate outcome showed excellent in 10 cases, good in 16 cases, fair in 4 cases, and the good rate was 86.7%. The anterior hybrid decompression can retain normal structure of the cervical spine through decompression, increase the fusion rate and efficiently improve the cervical physiological curvature and intervertebral height, thus it can be used in treatment of multilevel cervical spondylosis.Li Y, Shen CL, Zhang JX, Dong FL, Zhang RJ. Anterior hybrid decompression efficiently improves the cervical physiological curvature and intervertebral height in treatment of multilevel cervical spondylosis.Zhongguo Zuzhi Gongcheng Yanjiu. 2012;16(17): 3082-3086. [http://www.crter.cn http://en.zglckf.com]