BACKGROUND:: Studies have found that alginate dressing can accelerate wound healing, but the effects of treating refractory burn wound deserve further research. OBJECTIVE:: To observe the clinical therapeutic effects of alginate dressing on treating refractory burn wound. METHODS:: Sixty patients with refractory burn wound were randomly divided into control group with vaseline gauze and treatment group with alginate dressing. There were no significant differences in patientʼs age, gender, wound area and general conditions. The wound was changed dressing every 2- 3 days, until the wound healed. The healing period and healing rate, infection state, free skin graft, healing methods and healing quality of the patients in the two groups were observed and compared. RESULTS AND CONCLUSION:: The alginate dressing can shorten wound healing time, accelerate wound healing, decrease the wound infection and improve the healing quality. Compared with routine therapy, the alginate dressing dramatically reduce the wound healing time, can be used as one of the modalities for refractory burn wound.Huang GB, Zhang L, Zhang KY, Zhou L, Wu QH, Song GD. Therapeutic effects of alginate dressing for refractory burn wound: A randomized controlled study. Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2010;14(34):6355–6358. [http://www.crter.cn http://en.zglckf.com]