OBJECTIVE:: To compare the clinical effect of different materials for cranioplasty. METHODS:: The incidence rate of complication and the degree of moulding satisfaction of patients with skull defect which were repaired using net-added silica gel, auto-cranial bone, three-dimensional Ti frame and digital three-dimensional reconstructed Ti frame were retrospectively analyzed in the Department of Neurosurgery of Xixiang Peopleʼs Hospital from January 2000 to December 2007. RESULTS:: The incidence rate of complication and the degree of moulding satisfaction were 50% and 27.8% in the net-added silica gel group, 12.1% and 90.9% in the auto-cranial bone group, 27.3% and 45.5% in the three-dimensional Ti frame group, 5.6% and 100% in the digital three-dimensional reconstructed Ti frame group, respectively. The incidence rate of complication in the digital three-dimensional reconstructed Ti frame and auto-cranial bone groups was significantly lower than other two groups, while the degree of moulding satisfaction was also significantly different from other two groups (P < 0.05). CONCLUSION:: The digital three-dimensional reconstructed Ti frames and auto-cranial bone may cause few complications and achieve high degrees of moulding satisfaction for cranioplasty.Yu MJ, Chen HQ, Huang ZL.Clinical application of different materials for cranioplasty.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2009;13(21):4169-4172.[http://www.crter.cn http://en.zglckf.com]