Passenger Mutations Confound Interpretation of All Genetically Modified Congenic Mice
- Resource Type
- Academic Journal
- Authors
- Vanden Berghe, Tom; Hulpiau, Paco; Martens, Liesbet; Vandenbroucke, Roosmarijn E.; Van Wonterghem, Elien; Perry, Seth W.; Bruggeman, Inge; Divert, Tatyana; Choi, Sze Men; Vuylsteke, Marnik; Shestopalov, Valery I.; Libert, Claude; Vandenabeele, Peter
- Source
- Immunity. Jul 21, 2015 43(1):200-209
- Subject
- Language
- English
- ISSN
- 1074-7613
SUMMARY: GRAPHICAL ABSTRACT: (Figure is included in full-text article.) HIGHLIGHTS: : The importance of genetic background in genetically modified congenic mice is well known. Vanden Berghe and Vandenabeele and colleagues predict through comparative genomics (webtool) that nearly all 129-derived genetically modified congenic mice are affected by multiple inactivating passenger mutations despite intensive backcrossing and illustrate phenotypic interference through some case studies.