Introduction: Limited data are available on the effects of drug-eluting stents (DES) versus bare-metal stents (BMS) on rates of post-procedural bleeding and in-hospital mortality among patients who underwent percutaneous coronary intervention (PCI) for acute myocardial infarction (MI).Methods: This is a retrospective cohort study using the 2014 Nationwide Inpatient Sample (NIS) of adult patients hospitalized with MI as the admitting diagnosis who underwent PCI. We aim to determine if the type of stent affects the risk of post-procedural bleeding and in-hospital mortality. We adjusted our results for confounders including age, number of stents, type of MI, patient income, whether patient have insurance, hospital region and the Charlson Comorbidity Index.Results: We identified 53,894 patients (weighted n=269,470) admitted for MI who underwent PCI during 2014. Of the 53,894 patients, 81.7% received DES and 18.3% received BMS. Patients who received DES were younger and there was no significant gender difference between the two groups (Table 1). More bare metal stents were used in the ST-segment-elevation MI group compared to the non-ST-segment-elevation MI group (21.9% vs 15.3%; p<0.01). There was a 41% greater chance of post-procedural bleeding after PCI in the BMS group (Adjusted odds ratio (OR) 0.59, 95% CI 0.51—0.68%; p<0.01). The overall in-hospital mortality was 2.7% (95% CI, 2.5%-2.8%). Our analysis showed the chance of in-hospital mortality in the BMS group were 55% higher than the DES group (adjusted OR 0.45, 95% CI 0.40%—0.51%; p<0.01). The mean length of stay was longer among patients who received BMS (4.2 days vs 3.4 days; p<0.01); however, there was no significant difference in the adjusted cost of admission in both group.Conclusions: When compared with BMS, PCI with DES for acute MI was related with reduced in-hospital mortality, less post-procedural bleeding, and shorter length of stay.