Objectives: The purpose of this study was to identify the factors influencing the entrepreneurial intention of clinical nurses. Methods: The study subjects were 173 nurses working at the advanced general hospital located in G city. Data collection was conducted from May 18th to June 3rd, 2022. Data analysis were analyzed using percentage, mean and standard deviation, independent t-test, ANOVA, Scheffé test, Pearson’s correlation coefficient, and hierarchical multiple regression with the SPSS 25.0. Results: Entrepreneurial intention had a significant positive correlation with attitude toward entrepreneurship, subjective norm toward entrepreneurship, perceived behavior control toward entrepreneurship, innovativeness, proactiveness, risk-taking incentives and entrepreneurial self-efficacy. As a result of a hierarchical multiple regression analysis, gender (β=0.09, p=0.046), turnover intention (β=0.01, p=0.016), attitude toward entrepreneurship (β=0.51, p<0.001), and proactiveness (β=0.16, p<0.016) were found to significantly influence entrepreneurial intention of clinical nurses. The explanatory power of the model was 70.5% (F=35.87, p<0.001). Conclusions: Entrepreneurship for nurses can broaden the range of career options available to nurses, and it can be a way to broaden their practice experience and provide a work-life balance. It is necessary to devise measures to activate nursing entrepreneurship based on the results of this study.