Ferric Reductase Activity of the ArsH Protein from Acidithiobacillus ferrooxidans
- Resource Type
- Article
- Authors
- Mo Hong Yu; Qian Chen; Juan Du; Lin Tang; Fang Qin; Bo Miao; Xue Ling Wu; Jia Zeng
- Source
- Journal of Microbiology and Biotechnology. May 30, 2011 21(5):464
- Subject
- Acidithiobacillus ferrooxidans
ArsH
flavoprotein
ferric reductase
- Language
- Korean
English
- ISSN
- 1017-7825
The arsH gene is one of the arsenic resistance system in bacteria and eukaryotes. The ArsH protein was annotated as a NADPH-dependent flavin mononucleotide (FMN) reductase with unknown biological function. Here we report for the first time that the ArsH protein showed high ferric reductase activity. Glu104 was an essential residue for maintaining the stability of the FMN cofactor. The ArsH protein may perform an important role for cytosolic ferric iron assimilation in vivo.