Background: Diabetes mellitus is associated with poor glycaemic control, and it is apublic health concern in Yemen. Recently, due to conflict situation in Yemen there areshortage of health care services and medication. Self-care behaviors represent costeffective intervention in the diabetes care management.Aim of Study: Investigate the factors influencing self-care behaviors among type IIdiabetic patients in Yemen.Methodology: A total of 344 type II DM patients were enrolled in a face to faceinterview administrated questionnaire which was guided by modified Summary of Self-Care Activities measure, as well as it studied knowledge level, sociodemographic, clinicalcharacteristics of the participants and respondents’ perspective for the main barriers topractice self-care during conflict situation in Yemen.Results: Only 28.5% of participants had good self-care practice, 42.6% fair and 29.4%poor, the highest self-care behavior score was taking medications while testing bloodglucose was the lowest. A significant association was identified between self-carebehaviors and participant age, gender, income status, diabetes duration, owningglucometer, following meal plan and level of knowledge related to diabetes.Conclusion: Diabetes self-care behaviors was inadequate among type II diabetic patientsin Yemen which emphasizes the role of health care providers to support patients withrequired knowledge and skills to improve their health outcome.