Mesoporous materials are defined as materials with pore sizes between 2 nm and 50 nm by IUPAC (International Union of Pore and Applied Chemistry). In this paper, N-doped mesoporous TiO2 was synthesized by templete free homogenous precipitation method, and the loading with Cu used the conventional impregnation method followed by calcination at 500℃. All prepared samples were characterized by X-ray diffraction (XRD), X-ray Photoelectron Spectroscopy (XPS), Field Emission-Scanning Electron Microscope (FE-SEM), the Brunaner-Emmett-Teller (BET) surface area analysis and Barrett-Joyner-Halenda (BJH) pore size distribution,and UV-Visible light diffusion spectroscopy (UV-Vis). And the photocatalytic activities were investigated by the decomposition gaseous Xylene under UV light and visible light respectively. From the results, it was found that as-prepared photocatalysts have an mesoporous structure (pore size between 4 and 10 nm and the surface area of NT30 (121.8 m2/g) is approximate twice than that in Degussa P25 (69.6 m2/g)) with subsitutional N by replacing the oxygen in the TiO2 lattice and CuO loaded on the surface of TiO2. The photocatalysts are huge sized spheres composed of large amount of small crystallites (7~13 nm) and more hydrophilic. The photocatalysts also exhibit visible light response, its activity is eight folds than that of Degussa P25 under visible light irradiation, while twice under UV light irradiation.