This work is mainly concerned with the synthesis of Co-Zn nanocomposites by employing MCM-41 silicaas hard template (CoZnO-HT) and its catalytic behavior toward to CO2 reforming with ethanol. The physicochemicalfeatures of the as-prepared catalysts were probed through various characterization techniques, including XRD, TEM,BET, H2-TPR, and XPS. Indeed, CoZnO-HT catalyst possessed a highly ordered mesostructure with similarity toMCM-41 template and a higher specific surface area (304m2/g) compared to the reference CoZnO-C sample (4.75m2/g) prepared by the conventional impregnation method. Consequently, CoZnO-HT exhibited good performance at lowtemperature, and full ethanol conversion could be achieved at 550 oC as well as the negligible formation of byproductacetone. In addition, this catalyst depicted good stability and no obvious deactivation was observed after 40 h time onstream tests under the stoichiometric feed ratio. Indeed, superior specific surface area and efficient mass transportwithin the mesopores might be critical factors assigned to better activity and stability for CoZnO-HT.